Abstract Search

ea0026p165 | Neuroendocrinology | ECE2011

Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians’ offspring

Vitale G , Brugts M P , Ogliari G , Castaldi D , Fatti L M , Hofland L J , Monti D , Cavagnini F , Franceschi C , Mari D , Janssen J A M J L

Increasing evidence has recently accumulated suggesting that IGF1 system is involved in the regulation of longevity. While in animal models alterations of IGF1 signalling increase life expectancy, in humans there are contradictory data. Centenarians are an extraordinary model to study human longevity, however, they present a number of drawbacks: rarity, frailty due to extreme age and lack of a control group of the same age. The availability of an age-matched control group is c...

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ea0029p1366 | Pituitary Clinical | ICEECE2012

An insight into the mechanisms underlying the sympathoinhibition of acromegaly

Carzaniga C. , Seravalle G. , Attanasio R. , Grassi G. , Lonati L. , Facchini C. , Cozzi R. , Fatti L. , Montini M. , Vitale G. , Sciortino G. , Damanti S. , Brambilla G. , Cavagnini F. , Mancia G. , Scacchi M. , Persani L.

By direct measurement of muscle sympathetic nerve activity (MSNA) we previously demonstrated a markedly decreased adrenergic tone in newly diagnosed acromegalic patients. The present study was aimed at confirming this finding in a larger group of patients and establishing the pathophysiological role of insulin resistance, GH and IGF1 levels, circulating leptin and extracellular water (ECW) in this abnormality.Study design: Fifteen de novo patients...

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Endocrine Abstracts

Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians’ offspring

An insight into the mechanisms underlying the sympathoinhibition of acromegaly

BiosciAbstracts